10 CFR 50 . 69 SSC Categorization Guideline
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CONCISE REPORT Detection of early impairment of coronary flow reserve in patients with systemic sclerosis
Objective: To investigate whether coronary flow reserve (CFR), measured by a new non-invasive method, is impaired early in patients with systemic sclerosis (SSc) and whether CFR impairment correlates with clinical or functional measures, or both. Methods: 27 patients with SSc without clinical evidence of ischaemic heart disease and 23 control group subjects matched for age and sex were studied....
متن کاملDetection of early impairment of coronary flow reserve in patients with systemic sclerosis.
OBJECTIVE To investigate whether coronary flow reserve (CFR), measured by a new non-invasive method, is impaired early in patients with systemic sclerosis (SSc) and whether CFR impairment correlates with clinical or functional measures, or both. METHODS 27 patients with SSc without clinical evidence of ischaemic heart disease and 23 control group subjects matched for age and sex were studied....
متن کاملBlunted coronary flow reserve in systemic sclerosis.
OBJECTIVES We investigated whether the non-invasive determination of coronary flow reserve (CFR), as evaluated by transthoracic Doppler echocardiography, might be a potential method to detect early dysfunction of cardiovascular system in patients affected by systemic sclerosis (SSc) without clinical signs or symptoms of cardiac impairment. The possible correlations between the CFR values and th...
متن کاملMechanism of coronary flow reserve reduction in systemic sclerosis: insight from intracoronary pressure wire studies.
OBJECTIVE Functional impairment of coronary microcirculation is thought to be a major pathway in the development of primary cardiac involvement in SSc; however, the underlying mechanism is not fully understood. We aimed to investigate the mechanisms of coronary flow reserve (CFR) reduction in patients with SSc. METHODS Seventeen SSc patients and 17 gender- and age-matched controls were enroll...
متن کاملPrognostic impact of coronary microcirculation abnormalities in systemic sclerosis: a prospective study to evaluate the role of non-invasive tests
INTRODUCTION Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome. METHODS Forty-one SSc patients, asymptomatic for coronary artery disease, were tested fo...
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